Immunoglobulin A and IgA deficiency mnemonic

IgA occurs as a monomer in the bloodstream and as a dimer when secreted (linked by the secretory component or a J chain attained from epithelial cells before secretion).

IgA is secreted onto mucosal surfaces (gastrointestinal, genitourinary, and respiratory) to block attachment of pathogens to mucous membranes.

Mnemonic: “ABCDE
A: Alone (Monomer)
B: in Blood
C: Component (Secretory component) or Chain (J chain) makes
D: Dimer
E: in Epithelial surfaces

What happens in IgA deficiency? Mnemonic!

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