How superantigens work

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Antigen presentation
Superantigens (SAgs) are a class of antigens which cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release.
Super antigen
Superantigens bind first to the MHC Class II and then coordinate to the variable alpha or beta chain of T-cell Receptors (TCR).


  1. Easiest way to understand the non-specificity of superantigen in regard to the binding of MHC II molecule to TCR of Helper T cell.