Table 5.1: Interleukins and their actions
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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Interleukin
|
Secreted by
|
Action
|
IL-1
|
Macrophages
|
Pyrogen,
macrophage activation.
|
IL-2
|
T
cells
|
T cell
proliferation.
|
IL-3
|
T
cells, thymic epithelial and stromal cells
|
Bone
marrow stimulation for hematopoiesis.
|
IL-4
|
Th2
cells
|
B-cell
activation, class switching to IgG and lgE, induces differentiation into Th2
cells.
|
IL-5
|
Th2
cells
|
Class
switching to IgA, eosinophil growth and differentiation.
|
IL-6
|
T
cells, macrophages
|
Acute
phase reactant, pyrogen, helps in T and B cell growth and differentiation.
|
IL-8
|
Macrophages
|
Neutrophil
recruitment
|
IL-10
|
Th2
cells, Treg cells
|
Inhibits
Th1 cells, inhibits cytokine release from macrophages.
|
IL-12
|
Macrophages
|
Activates
NK cells, induces CD4 T cell differentiation into Th1 cells.
|
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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