Interleukins and their actions

Table 5.1: Interleukins and their actions

Interleukin	Secreted by	Action
IL-1	Macrophages	Pyrogen, macrophage activation.
IL-2	T cells	T cell proliferation.
IL-3	T cells, thymic epithelial and stromal cells	Bone marrow stimulation for hematopoiesis.
IL-4	Th2 cells	B-cell activation, class switching to IgG and lgE, induces differentiation into Th2 cells.
IL-5	Th2 cells	Class switching to IgA, eosinophil growth and differentiation.
IL-6	T cells, macrophages	Acute phase reactant, pyrogen, helps in T and B cell growth and differentiation.
IL-8	Macrophages	Neutrophil recruitment
IL-10	Th2 cells, Treg cells	Inhibits Th1 cells, inhibits cytokine release from macrophages.
IL-12	Macrophages	Activates NK cells, induces CD4 T cell differentiation into Th1 cells.

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